The disappearance of a narrow Mg II absorption system in quasar SDSS J165501.31+260517.4

In this letter, we present for the first time, the discovery of the disappearance of a narrow Mg II $\lambda\lambda2796,2803$ absorption system from the spectra of quasar SDSS J165501.31+260517.4 ($z_{\rm e}=1.8671$). This absorber is located at $z_{\rm abs} =1.7877$, and has a velocity offset of $8,423\rm ~km~s^{-1}$ with respect to the quasar. According to the velocity offset and the line variability, this narrow Mg II $\lambda\lambda2796,2803$ absorption system is likely intrinsic to the quasar. Since the corresponding UV continuum emission and the absorption lines of another narrow Mg II $\lambda\lambda2796,2803$ absorption system at $z_{\rm abs}=1.8656$ are very stable, we think that the disappearance of the absorption system is unlikely to be caused by the change in ionization of absorption gas. Instead, it likely arises from the motion of the absorption gas across the line of sight

Efficiency and power of minimally nonlinear irreversible heat engines with broken time-reversal symmetry

We study the minimally nonlinear irreversible heat engines in which the time-reversal symmetry for the systems may b e broken. The expressions for the power and the efficiency are derived, in which the effects of the nonlinear terms due to dissipations are included. We show that, as within the linear responses, the minimally nonlinear irreversible heat engines enable attainment of Carnot efficiency at positive power. We also find that the Curzon-Ahlborn limit imposed on the efficiency at maximum power can be overcomed if the time-reversal symmetry is broken

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context. Squamous cell carcinoma (SCC) is a cancer of the squamous cell, which can occur in diverse human tissues. SCCs are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the pathogenesis of SCCs. In this review, evidences highlighting NOTCH's role in different types of SCCs are summarized. Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers. Finally, we discuss the convergent view on an intriguing possibility that Notch may function as tumor suppressor in SCCs across different tissues. These mechanistic insights into Notch signaling pathways will help to guide the research of SCCs and development of therapeutic strategies for these cancers

Analysis of the Teaching Strategy of English Continuation Task in Senior High School from the Perspective of Metacognitive Theory

With the emergence of new question type in the English reform of college Entrance examination, the academia has set off a research craze of "continuation task".This paper uses questionnaires and interviews with teachers to investigate and study the implementation, effect and existing problems of continuation task in senior high school English reading.Based on the teaching status and existing problems, this paper puts forward three strategies to improve the teaching effect of continuation task from the perspective of metacognitive theory, in order to help front-line English teachers in senior high schools effectively implement continuation task teaching, improve students' ability and level of continuation task, and thus improve students' English learning effect